Researchers at the University of Michigan Rogel Cancer Center have developed a new urine-based, multi-biomarker test to detect aggressive prostate cancer that performed better than existing biomarker tests in initial preclinical evaluations, according to a news release form the university.
The Urine Prostate Seq test, or UPSeq for short, uses next-generation genomic sequencing to analyze urine collected from men following a digital rectal exam.
The team used machine learning, a form of artificial intelligence, to zero in on 15 RNA transcripts that together create a “liquid biopsy” that outperformed the standard prostate-specific antigen blood test alone, a previous test developed at U-M called Michigan Prostate Score (MiPS) and several other existing biomarker tests, according to findings published in European Urology Oncology.
If a man is found to have an elevated PSA level, doctors first need to determine whether it’s a sign of prostate cancer, and if it is cancer, whether that cancer is aggressive. “The problem is that a patient can have multiple areas of cancer in the prostate and these areas may be different than each other,” explains senior study author Simpa Salami, MD, MPH, Assistant Professor of Urology at Michigan Medicine. “Because of this, both prostate biopsies and MRI scans can miss evidence of aggressive disease. So, this urine test is designed to tell us what’s really happening throughout the whole prostate.”
The research team believes the test has several potential clinical applications, including early detection of aggressive cancer in men at the time of an initial biopsy, and ruling out aggressive disease in men considering active surveillance – which involves monitoring their cancer through regular physical exams, blood tests, biopsies and imaging tests, and delaying treatment until the cancer shows signs of worsening.
