The National Institutes of Health (NIH) is awarding $5.4 million in first-year funding to establish a new program that supports the integration of genomics into learning health systems.
The new Genomics-enabled Learning Health System (gLHS) Network aims to identify and advance approaches for integrating genomic information into existing learning health systems. As genomic testing becomes increasingly common, more and more genomic data are available in clinical settings, and learning health systems present an opportunity to translate this evidence quickly and directly into improvements in medical care.
The network consists of six clinical study sites and a coordinating center, all of which have an operating learning health system. Each clinical site will propose a project that uses patient data to develop and refine some aspect of genomic medicine. These could include implementing testing for hereditary diseases or using genomic information to select which medications a patient is given.
The network also includes a coordinating center, which will select a set of projects that both seem feasible in the program’s five-year duration and have the potential to be shared throughout the network.
A major aim of the gLHS Network is to create generalizable knowledge and genomic medicine practices so that data collected at each clinical site can improve patient care more broadly. Beyond exchanging information within the network, the coordinating center will orchestrate sharing the network’s tools and resources with the greater clinical and scientific communities.
Such sharing practices have the potential to reach patients outside of hospitals with learning health systems. This includes many under-resourced settings, such as rural hospitals or other clinical settings in low-income areas.
The awards are jointly funded by NHGRI and the National Cancer Institute (NCI) and total $27 million, which will be distributed over the program’s five years, pending the availability of funds.
Coordinating center and principal investigators
Vanderbilt University Medical Center — Nashville, TN
- Josh F. Peterson, M.D., M.P.H.
- Carolyn Audet, Ph.D.
- Wesley Self, M.D., M.P.H.
Clinical sites and principal investigators
Boston Veterans Administration Research Institute — Boston, MA
- Jason Vassy, M.D., M.P.H.
- Maren Scheuner, M.D., M.P.H.
- Deepak Voora, M.D.
- Lori Orlando, M.D.
Geisinger Health System — Danville, PA
- Adam Buchanan, M.P.H.
Indiana University School of Medicine — Indianapolis, IN
- Todd C. Skaar, Ph.D.
- Paul R. Dexter, M.D.
Northwestern Medicine Feinberg School of Medicine — Chicago, IL
- Patricia D. Franklin, M.D., M.P.H.
- Elizabeth M. McNally, M.D., Ph.D.
- Lucy A. Godley, M.D., Ph.D.
- Rinad S. Beidas, Ph.D.
University of Utah Health—Salt Lake City, UT
- Kensaku Kawamoto, M.D., Ph.D.
- Mark Yandell, Ph.D.
- Martin Tristani-Firouzi, M.D.
Vanderbilt University Medical Center — Nashville, TN
- Dan Roden, M.D.
- Sunil Kripalani, M.D.
- Alexander Bick, M.D., Ph.D.
