The U.S. Preventive Services Task Force (USPSTF) found that the evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults, saying that more research is needed, according to a final recommendation statement.
The recommendation is consistent with the 2014 USPSTF statement.
Noting that total 25(OH)D levels can be measured by both binding and chemical assays, the USPSTF said, “serum total 25(OH)D levels are difficult to measure accurately, and different immunoassays can lead to underestimation or overestimation of total 25(OH)D levels. LC-MS/MS is considered the reference assay. However, LC-MS/MS is a complicated process and is subject to variation and error, including interference from other chemical compounds.”
