Owlstone Medical presents data demonstrating progress in development of breath biopsy test for the early detection of lung cancer
Owlstone Medical announced new data on the development of a screening test for the early detection of lung cancer. The results and research progress were presented in two posters at the EACR 2023 Congress, the annual meeting of the European Association for Cancer Research, held June 12-15 in Torino, Italy.
The poster ‘Proof-of-mechanism study for a diagnostic probe compound generating D5-ethanol as an on-breath reporter molecule for lung cancer – Evolution phase 1’ describes Owlstone’s efforts to establish D5-ethyl-ß-glucuronide as a non-invasive EVOC Probe for early cancer detection.
In-human clinical trials are now underway with Phase 1a (safety assessment in healthy humans) and Phase 1b (dose optimization study in subjects with and without lung cancer) of the EVOLUTION study almost complete. Preliminary results presented show excellent safety and tolerability and demonstrate proof of mechanism through the successful measurement of D5-Ethanol levels in breath samples from lung cancer patients.
The poster ‘Using exogenous volatile organic compound (EVOC) probes to target tumor-associated aldo-keto reductase activity: a potential tool to detect lung cancer’ describes a complementary EVOC probe approach for the early detection of lung cancer based on aldo-keto reductase (AKR) activity, a metabolic process linked with the body’s reaction to the damaging effects of high levels of oxidative stress from cancer. This study, performed in vitro on human lung cancer cells, evaluated the expression of AKRs and demonstrated the ability to measure AKR-associated volatile reporters from cancer cells.
