Study uses two sequencing methods to discover new mRNAs in neurodegenerative diseases
New study findings from Sanford Burnham Prebys could pave the way for future treatments for neurodegenerative diseases.
The research was led by Jerold Chun MD, PhD, and published in eNeuro. According to a press release, the researchers combined “two sequencing technologies in single cells to find new differences in mRNAs resulting from Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease (PD).”
Additionally, “The team used two forms of single-nucleus RNA sequencing (snRNAseq) in the study, which followed up on the landmark report in Science in 2016 from Chun and his collaborators about the use of snRNAseq in the human brain.”
The researchers analyzed over 165,000 cells and “used targeted long-read sequencing of mRNAs for the 50 genes most associated with the three neurodegenerative diseases in prior research.”
They found “new mRNA sequences from all 50 target genes.”
