History of COVID-19 doubles long-term risk of heart attack, stroke and death

Oct. 9, 2024
Research analysis reveals risk of cardiac events also varied by blood type and stays elevated for years after diagnosis.

A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California.

The study found that people with any type of COVID-19 infection were twice as likely to have a major cardiac event, such as heart attack, stroke or even death, for up to three years after diagnosis. The risk was significantly higher for patients hospitalized for COVID-19 and more of a determinant than a previous history of heart disease.

Further genetic analysis also revealed individuals with a blood type other than O (such as A, B or AB) were twice as likely to experience an adverse cardiovascular event after COVID-19 than those with an O-blood type.

Published in Arteriosclerosis, Thrombosis, and Vascular Biology, the researchers used UK Biobank data from 10,005 people who had COVID-19 and 217,730 people who did not get infected between February to December 2020.

Certain genetic variants are already linked to coronary artery disease, heart attack and COVID-19 infection. The researchers completed a genetic analysis to see if any of these known genetic variants contribute to elevated coronary artery disease risk after COVID-19. None of the known genetic variants were drivers of the enhanced cardiovascular events observed post COVID-19. Instead, the data highlighted an association between elevated risk and blood type.

Cleveland Clinic release on Newswise

ID 325303940 © Karina Schultze | Dreamstime.com
dreamstime_xxl_325303940
ID 24025028 © Hongqi Zhang (aka Michael Zhang) | Dreamstime.com
dreamstime_xxl_24025028
ID 196738515 © Norbert Dr. Lange | Dreamstime.com
dreamstime_xxl_196738515
ID 99829496 © Jarun011 | Dreamstime.com
dreamstime_xxl_99829496
ID 89045693 © Natal'ya Buzuevskaya | Dreamstime.com
dreamstime_xxl_89045693