Higher rates of new cases of dementia in a population over time — known as incident dementia — are linked to long-term exposure to fine particulate matter (PM2.5) air pollution, especially from agriculture and open fires, according to a study funded by the National Institutes of Health and published in JAMA Internal Medicine. Scientists found that 15% of older adults developed incident dementia during the average follow-up of 10 years.
University of Michigan, Ann Arbor, scientists used data from 27,857 adults aged 50 years and older enrolled in the Health and Retirement Study (HRS), a nationally representative cohort of older adults in the United States. Beginning in 1992, participants have been interviewed once every two years about many factors related to healthy aging, including their cognition, overall health, and health behaviors.
The research team also gathered air quality measurements from the U.S. Environmental Protection Agency; several other studies; and more than 300 geographic variables such as nearby transportation, land cover and use, population density, emission sources, and vegetation. This information was applied to a prediction model to estimate total PM2.5 at participants' residential addresses. The model multiplied total PM2.5 concentration at individual addresses by local fractions of PM2.5 attributable to each of nine emission sources: agriculture, road traffic, non-road traffic, coal combustion for energy production, other energy production, coal combustion for industry, other industry, open fires, and windblown dust.
The findings showed 4,105 participants (15%) developed dementia during the follow-up period. Compared with those who did not develop dementia, participants with incident dementia were more likely to be non-white, have less formal education, less wealth, and higher surrounding PM2.5 levels at their address. While agriculture and open fires had the strongest air pollution-dementia associations, road traffic, non-road traffic, and coal combustion for energy production and industry were also associated with incident dementia.
The study advances the scientific literature by examining associations of incident dementia with PM2.5 from key emission sources rather than just total PM2.5. The findings suggest interventions that reduce air pollution may decrease the lifelong risk of developing dementia.
